Anti-CXCR1 antibody (ab124344)
Key features and details
- Rabbit polyclonal to CXCR1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CXCR1 antibody
See all CXCR1 primary antibodies -
Description
Rabbit polyclonal to CXCR1 -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species IHC-P HumanWB Human
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Immunogen
Synthetic peptide derived from the N terminus of Human CXCR1 (NP_000625).
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Positive control
- Human fetal skin lysate; Human fetal tonsil tissue.
Properties
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Form
Lyophilized:Reconstitute in 200:micro;l of sterile H2O.
The lyophilized antibody is stable for at least one year when stored at -20ºC after reconstitution. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab124344 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| IHC-P |
Human
|
| WB |
Human
|
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 40 kDa.
|
|
| IHC-P |
1/100 - 1/500.
|
| Notes |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 40 kDa. |
|
IHC-P
1/100 - 1/500. |
Target
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Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 3577 Human
- Omim: 146929 Human
- SwissProt: P25024 Human
- Unigene: 194778 Human
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Alternative names
- C C antibody
- C C CKR 1 antibody
- C-X-C chemokine receptor type 1 antibody
see all
Images
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Western blot - Anti-CXCR1 antibody (ab124344)Anti-CXCR1 antibody (ab124344) at 1/500 dilution + Human fetal skin lysate.
Predicted band size: 40 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR1 antibody (ab124344)ab124344, at 1/100 dilution, staining CXCR1 in formalin-fixed, paraffin-embedded Human fetal tonsil tissue.
Protocols
References (3)
ab124344 has been referenced in 3 publications.
- Ilgin C et al. The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer. Histol Histopathol N/A:18139 (2019). PubMed: 31250425
- Wang S et al. miR-761 inhibits human osteosarcoma progression by targeting CXCR1. Int J Clin Exp Pathol 11:5327-5334 (2018). PubMed: 31949613
- Kokje VBC et al. CXCL8 hyper-signaling in the aortic abdominal aneurysm. Cytokine 108:96-104 (2018). IHC-P ; Human . PubMed: 29587155
