Key features and details
- Mouse monoclonal [MM0221-7D22] to CXCR1
- Suitable for: IHC-Fr, Neutralising, Flow Cyt
- Reacts with: Human
- Isotype: IgG2a
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein G purified
Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography.
Our Abpromise guarantee covers the use of ab89251 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||1/20 - 1/100.|
|Neutralising||Use at an assay dependent concentration.|
|Flow Cyt||1/50 - 1/200.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
FunctionReceptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- C C antibody
- C C CKR 1 antibody
- C-X-C chemokine receptor type 1 antibody
ab89251 has been referenced in 1 publication.
- Liu TJ et al. CXC chemokine-7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial-mesenchymal transition signaling pathway. Mol Med Rep 16:6896-6903 (2017). PubMed: 28901471