ab194657 in conjunction with an compatible secondary reagent as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant CXCR2.
Use a concentration of 1.5 - 3 µg/ml.
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Belongs to the G-protein coupled receptor 1 family.
Phosphorylated upon ligand binding; which is required for desensitization.