Key features and details
- Rabbit polyclonal to CXCR2 (phospho S347)
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-CXCR2 (phospho S347) antibody
See all CXCR2 primary antibodies
DescriptionRabbit polyclonal to CXCR2 (phospho S347)
SpecificityDetects human CXCR2 only when phosphorylated at serine 347 (mouse: serine 346)
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Synthesized phosphopeptide derived from human CXCR2 around the phosphorylation site of serine 347 (R-P-SP-F-V).
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Our Abpromise guarantee covers the use of ab61100 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
FunctionReceptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsPhosphorylated upon ligand binding; which is required for desensitization.
Cellular localizationCell membrane.
- Information by UniProt
- C-X-C chemokine receptor type 2 antibody
- CD 182 antibody
- CD182 antibody
ab61100 has been referenced in 2 publications.
- Cunha F et al. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res 56:39-53 (2019). PubMed: 30995642
- Halpern JL et al. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett 308:91-9 (2011). WB, ICC/IF ; Mouse . PubMed: 21601983