Key features and details
- Rabbit polyclonal to CXCR3 - C-terminal
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-CXCR3 antibody - C-terminal
See all CXCR3 primary antibodies
DescriptionRabbit polyclonal to CXCR3 - C-terminal
SpecificityAt least two isoforms of CXCR3 are known to exist and ab181013 will detect both isoforms.
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human CXCR3 (C terminal). 19 amino acid peptide.
Database link: P49682-2
- WB: HepG2 cell lysate. ICC: HepG2 cells
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab181013 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 5 - 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa).|
FunctionReceptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis.
Isoform 3 mediates the activity of CXCL11.
Tissue specificityIsoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- C-X-C chemokine receptor type 3 antibody
- CD 183 antibody
- CD182 antibody
Lane 1 : Anti-CXCR3 antibody - C-terminal (ab181013) at 1 µg/ml
Lane 2 : Anti-CXCR3 antibody - C-terminal (ab181013) at 2 µg/ml
All lanes : HepG2 cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 46 kDa
Immunocytochemistry analysis of HepG2 cells labeling CXCR3 using ab181013 at 5 µg/ml.
ab181013 has been referenced in 2 publications.
- Lv ZT et al. FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-?B Activation and CXCL10 Expression. Biomed Res Int 2018:3936257 (2018). PubMed: 29977911
- Yu J et al. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. Int J Mol Med 40:1185-1193 (2017). PubMed: 28849106