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Immunology Innate Immunity Chemokines Alpha Chemokine Rec. (CXCR)
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RecombinantRabMAb

Recombinant Anti-CXCR3 antibody [EPR23845-44] (ab259865)

  • Datasheet
  • Certificate of Compliance
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Flow Cytometry - Anti-CXCR3 antibody [EPR23845-44] (ab259865)
  • Anti-CXCR3 antibody [EPR23845-44] (ab259865)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR23845-44] to CXCR3
  • Suitable for: Flow Cyt
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

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Overview

  • Product name

    Anti-CXCR3 antibody [EPR23845-44]
    See all CXCR3 primary antibodies
  • Description

    Rabbit monoclonal [EPR23845-44] to CXCR3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cytmore details
    Unsuitable for: ICC,IHC-P,IP or WB
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • Flow cyt: Human peripheral blood mononuclear cells.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR23845-44
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Chemokines
    • Alpha Chemokine Rec. (CXCR)
    • Signal Transduction
    • Signaling Pathway
    • Calcium Signaling
    • Other
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR
    • Cardiovascular
    • Atherosclerosis
    • Vascular Inflammation
    • Leukocyte recruitment
    • Chemokines

Associated products

  • Alternative Versions

    • Anti-CXCR3 antibody [EPR23845-44] - BSA and Azide free (ab274420)
  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab259865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
1/500.
Notes
Flow Cyt
1/500.
Application notes
Is unsuitable for ICC,IHC-P,IP or WB.

Target

  • Function

    Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
    Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis.
    Isoform 3 mediates the activity of CXCL11.
  • Tissue specificity

    Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession P49682 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 2833 Human
    • Omim: 300574 Human
    • SwissProt: P49682 Human
    • Unigene: 198252 Human
    • Alternative names

      • C-X-C chemokine receptor type 3 antibody
      • CD 183 antibody
      • CD182 antibody
      • CD183 antibody
      • Chemokine (C X C motif) receptor 3 antibody
      • Chemokine (C X C) receptor 3 antibody
      • Chemokine CXC Motif Receptor 3 antibody
      • CKR L2 antibody
      • CKR-L2 antibody
      • CKRL2 antibody
      • CMKAR3 antibody
      • CXC-R3 antibody
      • CXCR-3 antibody
      • CXCR3 antibody
      • CXCR3_HUMAN antibody
      • G Protein Coupled Receptor 9 antibody
      • G protein-coupled receptor 9 antibody
      • GPR9 antibody
      • Interferon-inducible protein 10 receptor antibody
      • IP-10 receptor antibody
      • IP10 antibody
      • IP10 R antibody
      • IP10 receptor antibody
      • IP10-R antibody
      • IP10R antibody
      • Mig R antibody
      • Mig receptor antibody
      • Mig-R antibody
      • MIGR antibody
      see all

    Images

    • Flow Cytometry - Anti-CXCR3 antibody [EPR23845-44] (ab259865)
      Flow Cytometry - Anti-CXCR3 antibody [EPR23845-44] (ab259865)

      Flow cytometric analysis of human peripheral blood mononuclear cells (PBMC) (treated with 200U/ml Interleukin-2 (IL-2) and 1µg/ml Phytohemagglutinin (PHA) for 6 days) labelling CXCR3 with ab259865 at 1/500 dilution (0.1µg) (Right) compared with a Rabbit monoclonal IgG (ab172730) isotype control (Left). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.

      Cells were stained with rabbit IgG or ab259865. Then stained with anti-CD3 conjugated to Alexa Fluor® 647.

      Gated on viable cells.

    • Anti-CXCR3 antibody [EPR23845-44] (ab259865)
      Anti-CXCR3 antibody [EPR23845-44] (ab259865)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    Certificate of Compliance

    To download a Certificate of Compliance, please enter your Lot number below:

    References (0)

    Publishing research using ab259865? Please let us know so that we can cite the reference in this datasheet.

    ab259865 has not yet been referenced specifically in any publications.

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