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    cxcr6-antibody-ab8023.pdf

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Microbiology Interspecies Interaction Host Virus Interaction
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Anti-CXCR6 antibody (ab8023)

  • Datasheet
Reviews (1) Submit a question References (8)

Product price, shipping and contact information

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Immunofluorescence - Anti-CXCR6 antibody (ab8023)
  • Western blot - Anti-CXCR6 antibody (ab8023)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR6 antibody (ab8023)

Key features and details

  • Rabbit polyclonal to CXCR6
  • Suitable for: IHC-P, WB
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-CXCR6 antibody
    See all CXCR6 primary antibodies
  • Description

    Rabbit polyclonal to CXCR6
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IF
    Human
    IHC-P
    Human
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide, corresponding to amino acids 11-25 of Human Bonzo.

  • Positive control

    • Human spleen tissue lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Microbiology
    • Interspecies Interaction
    • Host Virus Interaction
    • Immunology
    • Immune System Diseases
    • Antiviral Signaling
    • HIV-related

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Conjugation kits

    • PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (ab102918)
    • APC Conjugation Kit - Lightning-Link® (ab201807)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab8023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IF
Human
IHC-P
Human
WB
Human
Application Abreviews Notes
IHC-P
Use a concentration of 2.5 - 20 µg/ml.
WB
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa.
IF
Use a concentration of 20 µg/ml.
Notes
IHC-P
Use a concentration of 2.5 - 20 µg/ml.
WB
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa.
IF
Use a concentration of 20 µg/ml.

Target

  • Function

    Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
  • Tissue specificity

    Expressed in lymphoid tissues and activated T cells.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession O00574 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 10663 Human
    • Omim: 605163 Human
    • SwissProt: O00574 Human
    • Unigene: 34526 Human
    • Alternative names

      • bonzo antibody
      • C X C chemokine receptor type 6 antibody
      • C-X-C chemokine receptor type 6 antibody
      • CD 186 antibody
      • CD186 antibody
      • CD186 antigen antibody
      • CDw186 antibody
      • Chemokine (C X C motif) receptor 6 antibody
      • Chemokine C X C motif receptor 6 antibody
      • Chemokine CXC motif receptor 6 antibody
      • Chemokine receptor 6 antibody
      • CXC chemokine receptor type 6 antibody
      • CXC R6 antibody
      • CXC-R6 antibody
      • CXCR 6 antibody
      • CXCR-6 antibody
      • CXCR6 antibody
      • CXCR6_HUMAN antibody
      • G protein coupled receptor antibody
      • G protein coupled receptor bonzo antibody
      • G protein coupled receptor STRL 33 antibody
      • G protein coupled receptor STRL33 antibody
      • G protein coupled receptor TYMSTR antibody
      • G-protein coupled receptor bonzo antibody
      • G-protein coupled receptor STRL33 antibody
      • STRL 33 antibody
      • STRL33 antibody
      • TYMSTR antibody
      see all

    Images

    • Immunofluorescence - Anti-CXCR6 antibody (ab8023)
      Immunofluorescence - Anti-CXCR6 antibody (ab8023)

      Immunofluorescence of human spleen tissue labeling CXCR6 (Green) using ab8023 at 20 µg/ml. DAPI staining (Blue).

    • Western blot - Anti-CXCR6 antibody (ab8023)
      Western blot - Anti-CXCR6 antibody (ab8023)
      All lanes : Anti-CXCR6 antibody (ab8023) at 1/500 dilution

      Lane 1 : human spleen tissue lysate with absence of peptide
      Lane 2 : human spleen tissue lysate with presence of peptide

      Predicted band size: 44 kDa
      Observed band size: 44 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR6 antibody (ab8023)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR6 antibody (ab8023)

      ab8023 at 20µg/ml staining CXCR6 in human spleen cells by IHC

    Protocols

    • Flow cytometry protocols
    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (8)

    Publishing research using ab8023? Please let us know so that we can cite the reference in this datasheet.

    ab8023 has been referenced in 8 publications.

    • Tu GW  et al. CXCL16/CXCR6 is involved in LPS-induced acute lung injury via P38 signalling. J Cell Mol Med 23:5380-5389 (2019). PubMed: 31199046
    • Li S  et al. Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes. J Allergy Clin Immunol 140:177-189.e9 (2017). PubMed: 27826097
    • Ke C  et al. Association between CXCL16/CXCR6 expression and the clinicopathological features of patients with non-small cell lung cancer. Oncol Lett 13:4661-4668 (2017). PubMed: 28599467
    • Cui W  et al. miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA. Biochem Biophys Res Commun 479:901-906 (2016). PubMed: 27641667
    • Sun JJ  et al. MicroRNA-361-5p Inhibits Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma. Cell Physiol Biochem 38:777-85 (2016). PubMed: 26872014
    • Sellerio AL  et al. Overshoot during phenotypic switching of cancer cell populations. Sci Rep 5:15464 (2015). PubMed: 26494317
    • Toiyama Y  et al. Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer. Int J Oncol 40:560-6 (2012). PubMed: 22038159
    • Manabe S  et al. Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues. Arch Gynecol Obstet 284:1567-72 (2011). IHC-P ; Human . PubMed: 21773780

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Flow Cytometry abreview for Anti-Bonzo antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Flow Cytometry
    Sample
    Human Cell (human cancer cell line MCF-7)
    Specification
    human cancer cell line MCF-7
    Permeabilization
    No
    Gating Strategy
    LIVE
    Read More

    Abcam user community

    Verified customer

    Submitted May 28 2010

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