Anti-CXCR6 antibody (ab8023)
Key features and details
- Rabbit polyclonal to CXCR6
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CXCR6 antibody
See all CXCR6 primary antibodies -
Description
Rabbit polyclonal to CXCR6 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide, corresponding to amino acids 11-25 of Human Bonzo.
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Positive control
- Human spleen tissue lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
Use a concentration of 2.5 - 20 µg/ml.
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| WB |
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa.
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| IF |
Use a concentration of 20 µg/ml.
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| Notes |
|---|
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IHC-P
Use a concentration of 2.5 - 20 µg/ml. |
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WB
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa. |
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IF
Use a concentration of 20 µg/ml. |
Target
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Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. -
Tissue specificity
Expressed in lymphoid tissues and activated T cells. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 10663 Human
- Omim: 605163 Human
- SwissProt: O00574 Human
- Unigene: 34526 Human
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Alternative names
- bonzo antibody
- C X C chemokine receptor type 6 antibody
- C-X-C chemokine receptor type 6 antibody
see all
Images
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Immunofluorescence - Anti-CXCR6 antibody (ab8023)
Immunofluorescence of human spleen tissue labeling CXCR6 (Green) using ab8023 at 20 µg/ml. DAPI staining (Blue).
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Western blot - Anti-CXCR6 antibody (ab8023)All lanes : Anti-CXCR6 antibody (ab8023) at 1/500 dilution
Lane 1 : human spleen tissue lysate with absence of peptide
Lane 2 : human spleen tissue lysate with presence of peptide
Predicted band size: 44 kDa
Observed band size: 44 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR6 antibody (ab8023)ab8023 at 20µg/ml staining CXCR6 in human spleen cells by IHC
Protocols
Datasheets and documents
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Datasheet download
References (9)
ab8023 has been referenced in 9 publications.
- Zhang J et al. Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis. Biomed Res Int 2021:8883800 (2021). PubMed: 33829065
- Tu GW et al. CXCL16/CXCR6 is involved in LPS-induced acute lung injury via P38 signalling. J Cell Mol Med 23:5380-5389 (2019). PubMed: 31199046
- Li S et al. Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes. J Allergy Clin Immunol 140:177-189.e9 (2017). PubMed: 27826097
- Ke C et al. Association between CXCL16/CXCR6 expression and the clinicopathological features of patients with non-small cell lung cancer. Oncol Lett 13:4661-4668 (2017). PubMed: 28599467
- Cui W et al. miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA. Biochem Biophys Res Commun 479:901-906 (2016). PubMed: 27641667
- Sun JJ et al. MicroRNA-361-5p Inhibits Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma. Cell Physiol Biochem 38:777-85 (2016). PubMed: 26872014
- Sellerio AL et al. Overshoot during phenotypic switching of cancer cell populations. Sci Rep 5:15464 (2015). PubMed: 26494317
- Toiyama Y et al. Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer. Int J Oncol 40:560-6 (2012). PubMed: 22038159
- Manabe S et al. Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues. Arch Gynecol Obstet 284:1567-72 (2011). IHC-P ; Human . PubMed: 21773780
