Anti-CXCR6 antibody (ab8023)
Key features and details
- Rabbit polyclonal to CXCR6
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CXCR6 antibody
See all CXCR6 primary antibodies -
Description
Rabbit polyclonal to CXCR6 -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species IF HumanIHC-P HumanWB Human
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Immunogen
Synthetic peptide, corresponding to amino acids 11-25 of Human Bonzo.
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Positive control
- Human spleen tissue lysate
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| IF |
Human
|
| IHC-P |
Human
|
| WB |
Human
|
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
Use a concentration of 2.5 - 20 µg/ml.
|
|
| WB |
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa.
|
|
| IF |
Use a concentration of 20 µg/ml.
|
| Notes |
|---|
|
IHC-P
Use a concentration of 2.5 - 20 µg/ml. |
|
WB
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 44 kDa. |
|
IF
Use a concentration of 20 µg/ml. |
Target
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Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. -
Tissue specificity
Expressed in lymphoid tissues and activated T cells. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 10663 Human
- Omim: 605163 Human
- SwissProt: O00574 Human
- Unigene: 34526 Human
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Alternative names
- bonzo antibody
- C X C chemokine receptor type 6 antibody
- C-X-C chemokine receptor type 6 antibody
see all
Images
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Immunofluorescence - Anti-CXCR6 antibody (ab8023)
Immunofluorescence of human spleen tissue labeling CXCR6 (Green) using ab8023 at 20 µg/ml. DAPI staining (Blue).
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Western blot - Anti-CXCR6 antibody (ab8023)All lanes : Anti-CXCR6 antibody (ab8023) at 1/500 dilution
Lane 1 : human spleen tissue lysate with absence of peptide
Lane 2 : human spleen tissue lysate with presence of peptide
Predicted band size: 44 kDa
Observed band size: 44 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR6 antibody (ab8023)ab8023 at 20µg/ml staining CXCR6 in human spleen cells by IHC
Protocols
Datasheets and documents
References (8)
ab8023 has been referenced in 8 publications.
- Tu GW et al. CXCL16/CXCR6 is involved in LPS-induced acute lung injury via P38 signalling. J Cell Mol Med 23:5380-5389 (2019). PubMed: 31199046
- Li S et al. Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes. J Allergy Clin Immunol 140:177-189.e9 (2017). PubMed: 27826097
- Ke C et al. Association between CXCL16/CXCR6 expression and the clinicopathological features of patients with non-small cell lung cancer. Oncol Lett 13:4661-4668 (2017). PubMed: 28599467
- Cui W et al. miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA. Biochem Biophys Res Commun 479:901-906 (2016). PubMed: 27641667
- Sun JJ et al. MicroRNA-361-5p Inhibits Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma. Cell Physiol Biochem 38:777-85 (2016). PubMed: 26872014
- Sellerio AL et al. Overshoot during phenotypic switching of cancer cell populations. Sci Rep 5:15464 (2015). PubMed: 26494317
- Toiyama Y et al. Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer. Int J Oncol 40:560-6 (2012). PubMed: 22038159
- Manabe S et al. Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues. Arch Gynecol Obstet 284:1567-72 (2011). IHC-P ; Human . PubMed: 21773780
