Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor (ab146030)

Overview

  • Product name

    Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor
  • Description

    Cell-permeable transcriptional p53 inhibitor
  • Purity

    > 99%
  • CAS Number

    60477-38-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,6,7,8-Tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole
  • Molecular weight

    299.35
  • Molecular formula

    C15H13N3O2S
  • PubChem identifier

    4587369
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zuco V & Zunino F Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 10:587-96 (2008). Read more (PubMed: 18516295) »
  • Gudkov AV & Komarova EA Prospective therapeutic applications of p53 inhibitors. Biochem Biophys Res Commun 331:726-36 (2005). Read more (PubMed: 15865929) »
  • Barchéchath SD  et al. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem 48:6409-22 (2005). Read more (PubMed: 16190767) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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