Anti-Cyclin A1 antibody (ab172317)
Key features and details
- Mouse polyclonal to Cyclin A1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
-
Product name
Anti-Cyclin A1 antibody
See all Cyclin A1 primary antibodies -
Description
Mouse polyclonal to Cyclin A1 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rat -
Immunogen
Recombinant full length protein within Human Cyclin A1 aa 1 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (ABM85414.1).
Database link: P78396-2 -
Positive control
- Cyclin A1 transfected 293T cell line lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: 100% PBS -
Concentration information loading...
-
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab172317 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 52 kDa.
|
Notes |
---|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 52 kDa. |
Target
-
Function
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. -
Tissue specificity
Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines. -
Sequence similarities
Belongs to the cyclin family. Cyclin AB subfamily. -
Developmental stage
Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases. -
Cellular localization
Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 8900 Human
- Entrez Gene: 295052 Rat
- Omim: 604036 Human
- SwissProt: P78396 Human
- SwissProt: Q6AY13 Rat
- Unigene: 417050 Human
- Unigene: 102823 Rat
-
Alternative names
- CCN A1 antibody
- CCNA 1 antibody
- Ccna1 antibody
see all
Images
Datasheets and documents
-
Datasheet download
References (2)
ab172317 has been referenced in 2 publications.
- Ji W et al. c-myc regulates the sensitivity of breast cancer cells to palbociclib via c-myc/miR-29b-3p/CDK6 axis. Cell Death Dis 11:760 (2020). PubMed: 32934206
- Yang L et al. Transcriptional co-activator with PDZ-binding motif overexpression promotes cell proliferation and transcriptional co-activator with PDZ-binding motif deficiency induces cell cycle arrest in neuroblastoma. Oncol Lett 13:4295-4301 (2017). WB . PubMed: 28599430