Validated using a knockout cell line

Recombinant Anti-Cyclin B1 antibody [Y106] (ab32053)

Publishing research using ab32053? Please let us know so that we can cite the reference in this datasheet.

ab32053 has been referenced in 61 publications.

  • Sun J  et al. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem 121:443-457 (2020). PubMed: 31231887
  • Lin J  et al. Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma. Mol Carcinog 58:293-304 (2019). PubMed: 30334580
  • Brcic L  et al. Prognostic value of cyclin A2 and B1 expression in lung carcinoids. Pathology 51:481-486 (2019). PubMed: 31230818
  • Xie X  et al. Downregulation of G2/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells. Cell Death Dis 10:94 (2019). PubMed: 30700698
  • Dwivedi D  et al. The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis. J Cell Biol 218:871-894 (2019). PubMed: 30674580
  • Sun Z  et al. miR-181c-5p mediates simulated microgravity-induced impaired osteoblast proliferation by promoting cell cycle arrested in the G2 phase. J Cell Mol Med 23:3302-3316 (2019). PubMed: 30761733
  • Arceci A  et al. FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. Cell Rep 26:3076-3086.e6 (2019). PubMed: 30865895
  • Caller LG  et al. Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing. J Virol 93:N/A (2019). PubMed: 31142673
  • Buttarelli M  et al. A combined ANXA2-NDRG1-STAT1 gene signature predicts response to chemoradiotherapy in cervical cancer. J Exp Clin Cancer Res 38:279 (2019). PubMed: 31242951
  • Liu W  et al. Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells. Biomolecules 9:N/A (2019). PubMed: 31336757
  • Li J  et al. Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles. Int J Biol Sci 15:1755-1770 (2019). PubMed: 31360117
  • Xu L  et al. Silencing of heat shock protein 27 increases the radiosensitivity of non-small cell lung carcinoma cells. Mol Med Rep 20:613-621 (2019). PubMed: 31115576
  • Ren H  et al. Apolipoprotein C1 (APOC1) promotes tumor progression via MAPK signaling pathways in colorectal cancer. Cancer Manag Res 11:4917-4930 (2019). PubMed: 31213910
  • Yao S  et al. MicroRNA-376a regulates cell proliferation and apoptosis by targeting forkhead box protein P2 in lymphoma. Oncol Lett 16:3169-3176 (2018). PubMed: 30127911
  • Hewit K  et al. A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell Death Dis 9:1069 (2018). PubMed: 30341281
  • Zhang Y  et al. The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via ß-catenin/Cdc25c signaling and G2/M arrest. Clin Epigenetics 10:26 (2018). PubMed: 30359298
  • Wang Y & Kong D LncRNA GAS5 Represses Osteosarcoma Cells Growth and Metastasis via Sponging MiR-203a. Cell Physiol Biochem 45:844-855 (2018). PubMed: 29414815
  • Ding L  et al. CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer. Cell Death Dis 9:1172 (2018). PubMed: 30518842
  • Pan Y  et al. The ATRQß-001 vaccine improves cardiac function and prevents postinfarction cardiac remodeling in mice. Hypertens Res N/A:N/A (2018). PubMed: 30587854
  • Ding J  et al. Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma. BMB Rep 51:630-635 (2018). PubMed: 30293547
  • Giuliano CJ  et al. MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Elife 7:N/A (2018). PubMed: 29417930
  • Liu S & Liu B Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. Med Sci Monit 24:1424-1433 (2018). PubMed: 29519997
  • Ng PK  et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell 33:450-462.e10 (2018). PubMed: 29533785
  • Ruvolo PP  et al. Role of MSC-derived galectin 3 in the AML microenvironment. Biochim Biophys Acta 1865:959-969 (2018). PubMed: 29655803
  • Liu X Up-regulation of miR-20a by HPV16 E6 exerts growth-promoting effects by targeting PDCD6 in cervical carcinoma cells. Biomed Pharmacother 102:996-1002 (2018). WB . PubMed: 29710555
  • Li WL  et al. Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncol Rep 40:73-82 (2018). PubMed: 29749527
  • Liang HM  et al. By up-regulating µ- and d-opioid receptors, neuron-restrictive silencer factor knockdown promotes neurological recovery after ischemia. Oncotarget 8:101012-101025 (2017). PubMed: 29254142
  • Chamard-Jovenin C  et al. Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells. Front Endocrinol (Lausanne) 8:272 (2017). PubMed: 29109696
  • Zhao X  et al. Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. Oncol Lett 14:2177-2185 (2017). PubMed: 28789442
  • Song Z  et al. Overexpression and biological function of MEF2D in human pancreatic cancer. Am J Transl Res 9:4836-4847 (2017). PubMed: 29218083
  • Gurvits N  et al. Separase is a marker for prognosis and mitotic activity in breast cancer. Br J Cancer 117:1383-1391 (2017). PubMed: 28859055
  • Cao WJ  et al. Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells. Mol Med Rep 13:3297-302 (2016). PubMed: 26934953
  • Wang J  et al. A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO Rep 17:1452-1470 (2016). PubMed: 27496889
  • Zhou H  et al. RING1 and YY1 binding protein suppresses breast cancer growth and metastasis. Int J Oncol 49:2442-2452 (2016). PubMed: 27748911
  • Yang T  et al. Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375. Theranostics 6:142-54 (2016). WB ; Human . PubMed: 26722380
  • Tseng YH  et al. Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep 6:38756 (2016). Human . PubMed: 27934948
  • Zhang X  et al. MicroRNA-195 suppresses colorectal cancer cells proliferation via targeting FGF2 and regulating Wnt/ß-catenin pathway. Am J Cancer Res 6:2631-2640 (2016). WB ; Human . PubMed: 27904776
  • Yao Z  et al. shRNA-mediated silencing of the RFC3 gene suppresses hepatocellular carcinoma cell proliferation. Int J Mol Med 36:1393-9 (2015). WB ; Human . PubMed: 26397132
  • Strizzi L  et al. Effects of a novel Nodal-targeting monoclonal antibody in melanoma. Oncotarget 6:34071-86 (2015). PubMed: 26460952
  • Eriksson P  et al. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC Med Genomics 8:25 (2015). IHC-P ; Human . PubMed: 26008846
  • Wang Z  et al. Expression of CDK1(Tyr15), pCDK1(Thr161), Cyclin B1 (total) and pCyclin B1(Ser126) in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis. PLoS One 10:e0121398 (2015). IHC-P ; Human . PubMed: 25849598
  • Zhang Q  et al. TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner. Br J Cancer 113:1484-92 (2015). PubMed: 26512878
  • Gao K  et al. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Biochem Biophys Res Commun 458:849-55 (2015). WB ; Human . PubMed: 25689719
  • He X  et al. Functional repair of p53 mutation in colorectal cancer cells using trans-splicing. Oncotarget 6:2034-45 (2015). Human . PubMed: 25576916
  • Pan Y  et al. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition. Sci Rep 5:17006 (2015). PubMed: 26593394
  • Wang JF  et al. The molecular mechanisms of Tanshinone IIA on the apoptosis and arrest of human esophageal carcinoma cells. Biomed Res Int 2014:582730 (2014). WB ; Human . PubMed: 24829906
  • Wang H  et al. Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study. Chin Med 9:15 (2014). WB ; Human . PubMed: 24872842
  • Cornago M  et al. Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe. Cell Death Dis 5:e1435 (2014). WB, IF ; Human . PubMed: 25275596
  • Feng FL  et al. KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9. Int J Clin Exp Pathol 7:80-91 (2014). PubMed: 24427328
  • Zhu H  et al. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget 5:3455-71 (2014). WB . PubMed: 24797725
  • Magnussen GI  et al. High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients. BMC Cancer 13:288 (2013). WB ; Human . PubMed: 23767999
  • Khan S  et al. miR-379 regulates cyclin B1 expression and is decreased in breast cancer. PLoS One 8:e68753 (2013). PubMed: 23874748
  • Sjödahl G  et al. Toward a molecular pathologic classification of urothelial carcinoma. Am J Pathol 183:681-91 (2013). IHC-P ; Human . PubMed: 23827819
  • Gerdes MJ  et al. Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue. Proc Natl Acad Sci U S A 110:11982-7 (2013). IHC-P ; Human . PubMed: 23818604
  • Klintman M  et al. The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer. PLoS One 8:e81902 (2013). IHC ; Human . PubMed: 24324728
  • Moisan F  et al. Deciphering the role of the ERCC2 gene polymorphism on anticancer drug sensitivity. Carcinogenesis 33:962-8 (2012). WB . PubMed: 22345163
  • Nilsson C  et al. High proliferation is associated with inferior outcome in male breast cancer patients. Mod Pathol : (2012). IHC-P ; Human . PubMed: 22918167
  • He Y  et al. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One 7:e31087 (2012). WB . PubMed: 22348039
  • Hennessy BT  et al. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics 6:129-51 (2010). Dot blot ; Human . PubMed: 21691416
  • Niméus-Malmström E  et al. Cyclin B1 is a prognostic proliferation marker with a high reproducibility in a population-based lymph node negative breast cancer cohort. Int J Cancer 127:961-7 (2010). IHC ; Human . PubMed: 19957331
  • Kim WY  et al. A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res (Phila) 1:577-87 (2008). PubMed: 19139008

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