Anti-Cyclin Y antibody (ab114086)
Key features and details
- Rabbit polyclonal to Cyclin Y
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-Cyclin Y antibody
See all Cyclin Y primary antibodies -
Description
Rabbit polyclonal to Cyclin Y -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat -
Immunogen
Synthetic peptide corresponding to Human Cyclin Y. Between aa 291 and 341
Database link: Q8ND76 -
Positive control
- HeLa, 293T, NIH 3T3 and MCF7 whole cell lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7-8 -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab114086 was affinity purified using an epitope specific to Cyclin Y immobilized on solid support. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab114086 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2500. Predicted molecular weight: 39 kDa.
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Notes |
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WB
1/500 - 1/2500. Predicted molecular weight: 39 kDa. |
Target
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Function
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the cyclin family. Cyclin Y subfamily.
Contains 1 cyclin N-terminal domain. -
Developmental stage
Enriched at G2/M. -
Post-translational
modificationsUbiquitinated; leading to its degradation.
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. -
Cellular localization
Nucleus and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 613711 Cow
- Entrez Gene: 219771 Human
- Entrez Gene: 67974 Mouse
- Omim: 612786 Human
- SwissProt: Q8ND76 Human
- SwissProt: Q8BGU5 Mouse
- Unigene: 14745 Human
- Unigene: 564123 Human
see all -
Alternative names
- C10orf9 antibody
- CBCP1 antibody
- CCNX antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab114086 has been referenced in 2 publications.
- Gasa L et al. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. Sci Rep 7:10228 (2017). PubMed: 28860486
- Yan F et al. RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth. Oncol Rep 36:2793-2799 (2016). PubMed: 27666310