Cyclizine dihydrochloride, H1 receptor antagonist (ab145767)

Overview

  • Product name

    Cyclizine dihydrochloride, H1 receptor antagonist
  • Description

    H1 receptor antagonist
  • Biological description

    H1 receptor antagonist. Shows anticholinergic effects. Potentiates pentazocine-induced antinociception. Shows antiemetic, anti-inflammatory, antiallergic and antiplatelet effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    5897-18-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(Diphenylmethyl)-4-methylpiperazine dihydrochloride
  • Molecular weight

    339.30
  • Molecular formula

    C18H22N2.2HCl
  • PubChem identifier

    67533
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ahmadi A  et al. Synthesis and Anti-inflammatory Performance of Newly Cyclizine Derivatives on Adult Male Wistar Rats. Iran J Pharm Res 11:1027-37 (2012). Read more (PubMed: 24250533) »
  • Leza JC  et al. H1- and H2-histamine receptor blockers and opiate analgesia in mice. Methods Find Exp Clin Pharmacol 12:671-8 (1990). Read more (PubMed: 1983158) »
  • Yeh SY The effect of antihistaminic drugs on pentazocine antinociception in the rat. Pharmacol Biochem Behav 24:925-30 (1986). Read more (PubMed: 2872685) »

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