Overview

  • Product name

    Cyclocreatine, Creatine kinase substrate
  • Description

    Creatine kinase substrate. Creatine analog.
  • Biological description

    Creatine kinase substrate. Creatine analog. Regulates creatine biosynthesis. Suppresses arginine:glycine amidinotransferase levels. Shows antitumor effects in vivo.
  • CAS Number

    35404-50-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(2-Amino-4,5-dihydroimidazol-1-yl)acetic acid

  • Molecular weight

    143.15
  • Molecular formula

    C5H9N3O2
  • PubChem identifier

    2896
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1M HCl to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(C(=N1)N)CC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Enrico A  et al. Electrophysiology and biochemical analysis of cyclocreatine uptake and effect in hippocampal slices. J Integr Neurosci 12:285-97 (2013). Read more (PubMed: 23869866) »
  • Kurosawa Y  et al. Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. J Clin Invest 122:2837-46 (2012). Read more (PubMed: 22751104) »
  • Teicher BA  et al. Cyclocreatine in cancer chemotherapy. Cancer Chemother Pharmacol 35:411-6 (1995). Read more (PubMed: 7850923) »

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