Cycloheximide, Protein synthesis inhibitor (ab120093)

Submit a review Q&A (1)References (8)

Overview

  • Product name
    Cycloheximide, Protein synthesis inhibitor
  • Description
    Protein synthesis inhibitor
  • Biological description
    Protein synthesis inhibitor. Antifungal antibiotic.
  • Purity
    > 98%
  • CAS Number
    66-81-9
  • Chemical structure
    Chemical Structure

Properties

Applications

Our Abpromise guarantee covers the use of ab120093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • Functional Studies - Cycloheximide, Protein synthesis inhibitor (ab120093)
    Functional Studies - Cycloheximide, Protein synthesis inhibitor (ab120093)

    Functional assays: Caspase 8 (active) FITC Staining Kit (ab65614)

    Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.

References

This product has been referenced in:
  • Mattson MP & Furukawa K Anti-apoptotic actions of cycloheximide: blockade of programmed cell death or induction of programmed cell life? Apoptosis 2:257-64 (1997). Read more (PubMed: 14646539) »
  • Gokal PK  et al. The effects of cycloheximide upon transcription of rRNA, 5 S RNA, and tRNA genes. J Biol Chem 261:2536-41 (1986). Read more (PubMed: 2419318) »
  • Satav JG  et al. Study of protein synthesis in rat liver mitochondria use of cycloheximide. Eur J Biochem 73:287-96 (1977). Read more (PubMed: 837942) »
See all 8 Publications for this product

Publishing research using ab120093? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Phone call requesting information on how to open and how to handle Cycloheximide (ab120093).

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Answer

Thank you for contacting us on Friday.

I have been over to have a look at the pot of Cycloheximide (ab120093) which you would have received. The compound comes in a tamper safe vial, which should have come with a light blue "key" to open the pot. If you no longer have this key, a strong piece of plastic or metal of about a centimeter and a half should work. Something like a 2 pence coin should work. Simply place on the top of the vial, between the two notches and twist the lid. If you have any problems please do let us know and I'll try to explain it better.

As for handling the compound, the exact precautions that need to be taken to handle it safely can be seen in detail in the MSDS (attached to this email). Oncethe vial has been opened itshould be stored at4 degreesunder desiccating conditions.Itshould notbefrozen.If you do not feel comfortable handling this sort of compound I would suggest asking one of your colleagues in your department (such as the safely officer) for advice.

I hope this information has been of help.If you require any further information please do not hesitate tocontact us again.

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