Key features and details
- Cell-permeable Smo/Hh/GLI1 signaling inhibitor
- CAS Number: 306387-90-6
- Purity: > 80%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
Product nameCyclopamine-KAAD, Smo/Hh/GLI1 signaling inhibitor
DescriptionCell-permeable Smo/Hh/GLI1 signaling inhibitor
This product is manufactured by BioVision, an Abcam company and was previously called 1910 Cyclopamine-KAAD. 1910-50 is the same size as the 50 µg size of ab142146.
Chemical nameN-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8, 11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO and in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142146 has been referenced in 1 publication.
- Lau ST et al. Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Gastroenterology 157:1556-1571.e5 (2019). PubMed: 31442438