Overview

  • Product name

    Cyclopamine-KAAD, Smo/Hh/GLI1 signaling inhibitor
  • Description

    Cell-permeable Smo/Hh/GLI1 signaling inhibitor
  • Biological description

    Cell-permeable Smoothened, Sonic hedgehog and GLI1 signaling inhibitor. Cyclopamine derivative (ab120392). Suppresses the constitutive pathway activation resulting from loss of Ptch1 function (IC50 = 20 nM).
  • Purity

    > 80%
  • CAS Number

    306387-90-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8, 11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
  • Molecular weight

    697.99
  • Molecular formula

    C44H63N3O4
  • PubChem identifier

    16760383
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Singh RR  et al. ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene 30:4874-86 (2011). Read more (PubMed: 21625222) »
  • Singh RR  et al. Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. Cancer Res 69:2550-8 (2009). Read more (PubMed: 19244133) »
  • Chen JK  et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99:14071-6 (2002). Read more (PubMed: 12391318) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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