Overview

  • Product name
    Cyclophosphamide, Alkylating agent
  • Description
    Alkylating agent; chemotherapeutic
  • Biological description
    Alkylating agent; pro-drug capable of inducing DNA single-strand breaks. Efficacious in vitro and in vivo. Chemotherapeutic effects due to inhibition of Bax and Bcl-2 expression when administered with etoposide (ab120227).
  • Purity
    > 99%
  • CAS Number
    50-18-0
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Ackler S  et al. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother Pharmacol 66:869-80 (2010). Read more (PubMed: 20099064) »
  • Gibson LF  et al. Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy. Breast Cancer Res Treat 55:107-17 (1999). Read more (PubMed: 10481938) »
  • Hengstler JG  et al. DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin. Cancer Res 52:5622-6 (1992). Read more (PubMed: 1394186) »

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