Key features and details
- Ca2+-ATPase inhibitor
- CAS Number: 18172-33-3
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Penicillium grisefulvum
Product nameCyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor
- α-Cyclopiazonic acid
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Ion pumps / transporter
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120300 has been referenced in 5 publications.
- Rossi A et al. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Rep 30:2332-2348.e10 (2020). PubMed: 32075767
- Fedeli C et al. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy 15:2044-2062 (2019). PubMed: 30892128
- Clemens AM & Johnston D Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons. J Neurophysiol 111:1369-82 (2014). PubMed: 24381027
- Engbers JD et al. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A 109:2601-6 (2012). PubMed: 22308379
- Qu L et al. Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons. Brain Behav Immun 25:1399-407 (2011). PubMed: 21521651