Cyclosomatostatin, Somatostatin antagonist. (ab141211)

Overview

  • Product name

    Cyclosomatostatin, Somatostatin antagonist.
  • Description

    Somatostatin antagonist.
  • Biological description

    Somatostatin antagonist with various biological activities. Blocks the effect of somatostatin on β-adrenergic function and CRF-induced suppression of gastric empyting, ACh release and growth hormone, insulin, and glucagon release. May act as potent antiproliferative agonist in some cell lines.
  • Purity

    > 97%
  • CAS Number

    84211-54-1
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    779.98
  • Molecular formula

    C44H57N7O6
  • Sequence

    FWKT (Modifications: N-terminal aminoheptanoyl; Trp-2 = D-Trp; Thr-4 = Thr(Bn); Cyclised: 1-4)
  • PubChem identifier

    4195535
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 1mg/ml
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Benko R  et al. The putative somatostatin antagonist cyclo-somatostatin has opioid agonist effects in gastrointestinal preparations. Life Sci 90:728-32 (2012). Read more (PubMed: 22483686) »
  • Stirnweis J  et al. The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as potent antiproliferative agonist. Peptides 23:1503-6 (2002). Read more (PubMed: 12182954) »
  • Fischer L  et al. Adrenergic and non-adrenergic vasoconstrictor mechanisms in the human nasal mucosa. Rhinology 31:11-5 (1993). Read more (PubMed: 8100640) »
  • Fries JL  et al. Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat. Peptides 3:811-4 (0). Read more (PubMed: 6129618) »
See 1 Publication for this product

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