- References (4)
Product nameCyclosporin A, PP2B inhibitor
Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B). Please see CofA for batch specific MW.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Yu DY et al. Effects of cyclosporin A, FK506 and rapamycin on calcineurin phosphatase activity in mouse brain. IUBMB Life 58:429-33 (2006). Read more (PubMed: 16801218) »
- Ho S et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 80:S40-5 (1996). Read more (PubMed: 8811062) »
- Liu J FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol Sci 14:182-8 (1993). Read more (PubMed: 7692652) »