Overview

  • Product name

    Cyclosporin D, TPA/PMA inhibitor
  • Description

    TPA/PMA inhibitor with multiple biological activities
  • Biological description

    TPA/PMA inhibitor with multiple biological activities. Inhibitor of Ca2+/calmodulin dependent EF2 phosphorylation. Potent inhibitor of P. falciparum growth (IC50 = 32 nM). Anti-malariant and weak immunosuppressant. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    63775-96-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1216.64
  • Molecular formula

    C63H113N11O12
  • PubChem identifier

    6436250
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O
  • Source

    Fusarium solani

  • Research areas

References

This product has been referenced in:

  • Bell A  et al. Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 48:495-503 (1994). Read more (PubMed: 7520696) »
  • Gschwendt M  et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun 150:545-51 (1988). Read more (PubMed: 3342035) »
  • Sadeg N  et al. In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21. Immunopharmacol Immunotoxicol 15:163-77 (0). Read more (PubMed: 8349948) »

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