Overview

  • Product name
    Cyclosporin H, TPA/PMA inhibitor
  • Description
    TPA/PMA inhibitor
  • Biological description
    TPA/PMA inhibitor. Selective inhibitor of formyl peptide receptors (Ki = 0.1 µM). Inhibits Ca2+/calmodulin dependent EF-2 phosphorylation. Inhibits FMLP-induced superoxide anion formation (IC50 = 40 nM). Multiple biological effects.
  • Purity
    > 96%

Properties

References

This product has been referenced in:
  • Wenzel-Seifert K & Seifert R Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J Immunol 150:4591-9 (1993). Read more (PubMed: 8387097) »
  • Wenzel-Seifert K  et al. Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. J Immunol 147:1940-6 (1991). Read more (PubMed: 1653806) »
  • Gschwendt M  et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun 150:545-51 (1988). Read more (PubMed: 3342035) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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