Overview

  • Product name
    Cyclothiazide, AMPA receptor desensitisation inhibitor
  • Description
    AMPA receptor desensitisation inhibitor
  • Biological description
    Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Also available in Kit: Ionotropic agonists (ab120323).
  • Purity
    > 98%
  • CAS Number
    2259-96-3
  • Chemical structure
    Chemical Structure

Properties

Associated products

Images

  • To determine the capability of VCN-LSO synapses to support repetitive activity in the developing circuit, we added cyclothiazide to the perfusate to prevent AMPAR desensitization and measured responses to 50 Hz pulse-train stimuli delivered to the ventral acoustic stria. A. Representative responses to 50 Hz pulse-trains in P2, P5, and P9 cells; responses to the first five pulses only are shown. Greater paired-pulse depression between pulse 1 and 2 is evident in the youngest cell than in the older cells.

References

This product has been referenced in:
  • Fucile S  et al. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A 103:2943-7 (2006). Read more (PubMed: 16473938) »
  • Desai MA  et al. Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists. J Pharmacol Exp Ther 272:38-43 (1995). Read more (PubMed: 7529311) »
  • Partin KM  et al. Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Mol Pharmacol 46:129-38 (1994). Read more (PubMed: 8058047) »
See all 15 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120061.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up