Overview

  • Product name
    Cyclovirobuxin D (Bebuxine), Ca2+ modulator
  • Description
    Intracellular Ca2+ modulator
  • Biological description
    Intracellular Ca2+ modulator. Decreases the L-type Ca2+ current and increases intracellular calcium mobilization. Shows anti-ischemic and vasodilatory effects in vivo.
  • Purity
    > 99%

Properties

  • Molecular weight
    402.66
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C26H46N2O
  • CAS Number
    860-79-7
  • PubChem identifier
    260439
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1[C@@H](C([C@]2([C@]3(C1)[C@@]4([C@@](CC2)([C@]5([C@](CC4)([C@@]([C@@H](C5)O)([C@H](C)NC)[H])C)C)[H])C3)[H])(C)C)NC
  • Source

    Buxus microphylla

  • Research areas

References

This product has been referenced in:
  • Yu B  et al. Influence of cyclovirobuxine D on intracellular [Ca(2+)] regulation and the expression of the calcium cycling proteins in rat myocytes. Fitoterapia 83:1653-65 (2012). Read more (PubMed: 23022536) »
  • Yu B  et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia 82:868-77 (2011). Read more (PubMed: 21575690) »
  • Grossini E  et al. Regulation of Ca2+ movements by cyclovirobuxine D in ECV304 endothelial cells. Pharmacol Res 52:154-61 (2005). Read more (PubMed: 15967381) »
  • Chen QW  et al. [Effects of cyclovirobuxine D on intracellular Ca2+ and L-type Ca2+ current in rat ventricular cardiomyocytes]. Yao Xue Xue Bao 39:500-3 (2004). Read more (PubMed: 15493836) »
  • Grossini E  et al. Coronary effects of cyclovirobuxine D in anesthetized pigs and in isolated porcine coronary arteries. Life Sci 65:PL59-65 (1999). Read more (PubMed: 10462084) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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