• Product name
  • Description
    Rabbit polyclonal to CYP11B1
  • Host species
  • Specificity
    This antibody reacts specifically with 60 kDa CYP11B1 protein.
  • Tested applications
    Suitable for: IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Japanese ricefish
  • Immunogen

    Synthetic peptide derived from the C-terminal domain of (Oryzias latipes) CYP11B1.


Our Abpromise guarantee covers the use of ab71561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
WB 1/100 - 1/1000. Predicted molecular weight: 60 kDa.Can be blocked with Japanese ricefish CYP11B1 peptide (ab203375).


  • Relevance
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. Defects in CYP11B1 are the cause of adrenal hyperplasia type 4 (AH4) [MIM:202010]. AH4 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic). AH4 patients usually have hypertension.
  • Cellular localization
    Mitochondrion inner membrane.
  • Alternative names
    • CPN1 antibody
    • CYP11B antibody
    • CYPXIB1 antibody
    • Cytochrome P 450c11 antibody
    • Cytochrome P450 11B1, mitochondrial antibody
    • Cytochrome p450 XIB1 antibody
    • Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody
    • Cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1 antibody
    • Cytochrome P450, subfamily XIB, polypeptide 1 antibody
    • Cytochrome P450C11 antibody
    • FHI antibody
    • P 450C11 antibody
    • P450C11 antibody
    • S11BH antibody
    • Steroid 11 beta hydroxylase antibody
    • Steroid 11 beta monooxygenase antibody
    see all


This product has been referenced in:
  • Pfennig F  et al. The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression. Reproduction 143:71-84 (2012). IHC ; Tilapia . Read more (PubMed: 22031714) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for your inquiry.

I can confirm that the immunogen sequence used to develop the ab71561 does not present any homology with proteins from mouse and rat.

The sequence is specific of the C terminal part of Cytochrome P450 11b...

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