Overview

  • Product name

  • Description

    Goat polyclonal to CYP24A1
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Monkey, Gorilla, Common marmoset, Elephant
  • Immunogen

    Synthetic peptide corresponding to Human CYP24A1 aa 481-490 (internal sequence) (Cysteine residue). (NP_000773.2; NP_001122387.1).
    Sequence:

    RKYDIQATDN


    Database link: Q07973

  • Positive control

    • Human skin tissue; Human liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab189322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml.
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 59 kDa).

Target

  • Function

    Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1 25 @dihydroxyvitamin D3 24 hydroxylase antibody
    • 1 25 dihydroxyvitamin D(3) 24 hydroxylase antibody
    • 1 antibody
    • 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial antibody
    • 24 OHase antibody
    • 24-OHase antibody
    • 25-dihydroxyvitamin D(3) 24-hydroxylase antibody
    • CP 24 antibody
    • CP24 antibody
    • CP24A_HUMAN antibody
    • CYP 24 antibody
    • CYP24 antibody
    • CYP24A1 antibody
    • Cytochrome P450 24A1 antibody
    • Cytochrome P450 24A1 mitochondrial antibody
    • cytochrome P450 CC24 antibody
    • Cytochrome P450 family 24 antibody
    • Cytochrome P450 family 24 subfamily A member 1 antibody
    • Cytochrome P450 family 24 subfamily A polypeptide 1 antibody
    • Cytochrome P450 subfamily XXIV antibody
    • Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) antibody
    • Cytochrome P450-CC24 antibody
    • EC 1.14.13.n4 antibody
    • Exo mitochondrial protein antibody
    • HCAI antibody
    • HCINF1 antibody
    • MGC126273 antibody
    • MGC126274 antibody
    • mitochondrial antibody
    • P450 CC24 antibody
    • Vitamin D 24 hydroxylase antibody
    • Vitamin D(3) 24 hydroxylase antibody
    • Vitamin D(3) 24-hydroxylase antibody
    see all

Images

  • Anti-CYP24A1 antibody (ab189322) at 0.1 µg/ml + Human liver lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 59 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue, labeling CYP24A1 with ab189322 at 3.75 µg/ml.

References

ab189322 has not yet been referenced specifically in any publications.

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