Key features and details
- Rabbit polyclonal to Cyp26B1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cyp26B1 antibody
See all Cyp26B1 primary antibodies
DescriptionRabbit polyclonal to Cyp26B1
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant full length protein corresponding to Human Cyp26B1.
Database link: P450 26B
- Human Adrenal gland and Human brain, cerebellum tissues; HepG2 whole cell lysate.
This product was previously labelled as Cytochrome P450 26B
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol, 79.99% Tris glycine
Concentration information loading...
PurityProtein A purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab113236 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 58 kDa.|
|IHC-P||Use a concentration of 10 µg/ml.|
FunctionInvolved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Tissue specificityHighly expressed in brain, particularly in the cerebellum and pons.
Involvement in diseaseRadiohumeral fusions with other skeletal and craniofacial anomalies
Sequence similaritiesBelongs to the cytochrome P450 family.
Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
- CP26 antibody
- CP26B_HUMAN antibody
- CYP26A2 antibody
ab113236, at 10µg/ml, staining Cyp26B1 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.
ab113236, at 10µg/ml, staining Cyp26B1 in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.
Anti-Cyp26B1 antibody (ab113236) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 58 kDa
7.5% SDS PAGE.
ab113236 has not yet been referenced specifically in any publications.