Anti-Cyp26B1 antibody (ab113640)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Cyp26B1 antibody
See all Cyp26B1 primary antibodies -
Description
Goat polyclonal to Cyp26B1 -
Host species
Goat -
Tested applications
Suitable for: ELISA, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Dog
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Immunogen
Synthetic peptide corresponding to Human Cyp26B1 aa 418-430 (internal sequence).
Sequence:C-SQARSEDKDGRFH
Database link: P450 26B -
Positive control
- Human spleen and small intestine (submucosal plexus) tissues; Human testis
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General notes
This product was previously labelled as Cytochrome P450 26B
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab113640 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | 1/128000. | |
| IHC-P | Use a concentration of 3.75 µg/ml. |
Target
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Function
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. -
Tissue specificity
Highly expressed in brain, particularly in the cerebellum and pons. -
Involvement in disease
Radiohumeral fusions with other skeletal and craniofacial anomalies -
Sequence similarities
Belongs to the cytochrome P450 family. -
Cellular localization
Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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Database links
- Entrez Gene: 56603 Human
- Entrez Gene: 232174 Mouse
- Entrez Gene: 312495 Rat
- Omim: 605207 Human
- SwissProt: Q9NR63 Human
- SwissProt: Q811W2 Mouse
- SwissProt: G3V7X8 Rat
- Unigene: 91546 Human
see all -
Alternative names
- CP26 antibody
- CP26B_HUMAN antibody
- CYP26A2 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human small intestine (submucosal plexus) tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.
Protocols
Datasheets and documents
References
ab113640 has not yet been referenced specifically in any publications.
