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    cyp26b1-antibody-ab113640.pdf

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Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cytochromes
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Anti-Cyp26B1 antibody (ab113640)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)

Key features and details

  • Goat polyclonal to Cyp26B1
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)

View more associated products

Overview

  • Product name

    Anti-Cyp26B1 antibody
    See all Cyp26B1 primary antibodies
  • Description

    Goat polyclonal to Cyp26B1
  • Host species

    Goat
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Human Cyp26B1 aa 400-500 (internal sequence).
    Database link: P450 26B

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Human spleen and small intestine (submucosal plexus) tissues; Human testis
  • General notes

     This product was previously labelled as Cytochrome P450 26B

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99% Tris buffered saline
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cytochromes
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipases
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Cytochromes
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
    • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
  • Isotype control

    • Goat IgG, polyclonal - Isotype Control (ab37373)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab113640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
All applications
Mouse
Rat
Dog
Application Abreviews Notes
IHC-P
Use a concentration of 3.75 µg/ml.
Notes
IHC-P
Use a concentration of 3.75 µg/ml.

Target

  • Function

    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
  • Tissue specificity

    Highly expressed in brain, particularly in the cerebellum and pons.
  • Involvement in disease

    Radiohumeral fusions with other skeletal and craniofacial anomalies
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Target information above from: UniProt accession Q9NR63 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 56603 Human
    • Entrez Gene: 232174 Mouse
    • Entrez Gene: 312495 Rat
    • Omim: 605207 Human
    • SwissProt: Q9NR63 Human
    • SwissProt: Q811W2 Mouse
    • SwissProt: G3V7X8 Rat
    • Unigene: 91546 Human
    • Unigene: 255246 Mouse
    • Unigene: 19898 Rat
    see all
  • Alternative names

    • CP26 antibody
    • CP26B_HUMAN antibody
    • CYP26A2 antibody
    • cyp26b1 antibody
    • Cytochrome P450 26A2 antibody
    • Cytochrome P450 26B1 antibody
    • Cytochrome P450 family 26 subfamily B polypeptide 1 antibody
    • Cytochrome P450 retinoic acid-inactivating 2 antibody
    • Cytochrome P450 retinoid metabolizing protein antibody
    • Cytochrome P450 subfamily XXVIA, polypeptide 2 antibody
    • Cytochrome P450 subfamily XXVIB polypeptide 1 antibody
    • Cytochrome P450RAI-2 antibody
    • DKFZp686G0638 antibody
    • dol antibody
    • EC 1.14. antibody
    • fc21d03 antibody
    • MGC129613 antibody
    • P450 26A2 antibody
    • P450 retinoic acid inactivating 2 antibody
    • P450RAI 2 antibody
    • P450RAI2 antibody
    • Retinoic acid metabolizing cytochrome antibody
    • Retinoic acid-metabolizing cytochrome antibody
    • RHFCA antibody
    • stocksteif antibody
    • wu:fc21d03 antibody
    • wu:fc26h10 antibody
    • zgc:76999 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)

    ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human small intestine (submucosal plexus) tissue by Immunohistochemistry.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)

    ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyp26B1 antibody (ab113640)

    ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.

Protocols

  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab113640? Please let us know so that we can cite the reference in this datasheet.

ab113640 has not yet been referenced specifically in any publications.

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