Overview

  • Product name

  • Description

    Rabbit polyclonal to Cyp26B1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHCmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish Cyp26B1 aa 180-445. The exact sequence is proprietary.
    Database link: Q6EIG3

  • Positive control

    • Zebrafish embryo tissue.
  • General notes

     This product was previously labelled as Cytochrome P450 26B

     

Properties

Applications

Our Abpromise guarantee covers the use of ab210567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC 1/100 - 1/1000.

Target

  • Function

    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
  • Tissue specificity

    Highly expressed in brain, particularly in the cerebellum and pons.
  • Involvement in disease

    Radiohumeral fusions with other skeletal and craniofacial anomalies
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

    • Alternative names

      • CP26 antibody
      • CP26B_HUMAN antibody
      • CYP26A2 antibody
      • cyp26b1 antibody
      • Cytochrome P450 26A2 antibody
      • Cytochrome P450 26B1 antibody
      • Cytochrome P450 family 26 subfamily B polypeptide 1 antibody
      • Cytochrome P450 retinoic acid-inactivating 2 antibody
      • Cytochrome P450 retinoid metabolizing protein antibody
      • Cytochrome P450 subfamily XXVIA, polypeptide 2 antibody
      • Cytochrome P450 subfamily XXVIB polypeptide 1 antibody
      • Cytochrome P450RAI-2 antibody
      • DKFZp686G0638 antibody
      • dol antibody
      • EC 1.14. antibody
      • fc21d03 antibody
      • MGC129613 antibody
      • P450 26A2 antibody
      • P450 retinoic acid inactivating 2 antibody
      • P450RAI 2 antibody
      • P450RAI2 antibody
      • Retinoic acid metabolizing cytochrome antibody
      • Retinoic acid-metabolizing cytochrome antibody
      • RHFCA antibody
      • stocksteif antibody
      • wu:fc21d03 antibody
      • wu:fc26h10 antibody
      • zgc:76999 antibody
      see all

    Images

    • Immunohistochemical analysis of agarose-embedded zebrafish tissue, labeling Cyp26B1 with ab210567 at 1/200 dilution.

    References

    ab210567 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab210567.
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