Key features and details
- Rabbit polyclonal to CYP2A6
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-CYP2A6 antibody
See all CYP2A6 primary antibodies
DescriptionRabbit polyclonal to CYP2A6
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Other Immunogen Type (His-tag) corresponding to Human CYP2A6. Purified, His-tagged, full length human P450 2A6 fusion protein.
- Rat liver lysate.
This product was previously labelled as Cytochrome P450 2A6
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: 99% PBS
Concentration information loading...
Primary antibody notesThe Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab3570 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/2000. Detects a band of approximately 49 kDa (predicted molecular weight: 57 kDa).
This antibody detects an ~49 kDa protein representing P450 2A6 from rat liver extract.
FunctionExhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.
Sequence similaritiesBelongs to the cytochrome P450 family.
Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
- Coumarin 7 hydroxylase antibody
- Coumarin 7-hydroxylase antibody
- CP2A6_HUMAN antibody
ab3570 has been referenced in 1 publication.
- Deng J et al. Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor ?. Drug Metab Dispos 46:1538-1545 (2018). PubMed: 30154104