Overview

  • Product name

    Anti-CYP2A6 antibody [F16 P2 D8]
    See all CYP2A6 primary antibodies
  • Description

    Mouse monoclonal [F16 P2 D8] to CYP2A6
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, ELISA, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CYP2A6 (C terminal) conjugated to ovalbumin.

  • General notes

     This product was previously labelled as Cytochrome P450 2A6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab56069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 54 kDa (predicted molecular weight: 57 kDa).
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 1 µg/ml.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.
  • Tissue specificity

    Liver.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Coumarin 7 hydroxylase antibody
    • Coumarin 7-hydroxylase antibody
    • CP2A6_HUMAN antibody
    • CPA6 antibody
    • CYP2A antibody
    • CYP2A3 antibody
    • CYP2A6 antibody
    • CYPIIA6 antibody
    • Cytochrome P450 2A6 antibody
    • Cytochrome P450 IIA3 antibody
    • Cytochrome P450 subfamily IIA (phenobarbital inducible) polypeptide 6 antibody
    • Cytochrome P450(I) antibody
    • Cytochrome P450, family 2 subfamily A polypeptide 6 antibody
    • Flavoprotein linked monooxygenase antibody
    • P450C2A antibody
    • P450PB antibody
    • Xenobiotic monooxygenase antibody
    see all

Images

  • Anti-CYP2A6 antibody [F16 P2 D8] (ab56069) at 1 µg/ml
    Predicted band size: 57 kDa
    Observed band size: 54 kDa
    why is the actual band size different from the predicted?

  • This image shows normal human liver tissue stained by ab56069 at 1µg/ml.

References

This product has been referenced in:

  • Dhamankar V  et al. Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. Inhal Toxicol 27:767-77 (2015). Read more (PubMed: 26572092) »
See 1 Publication for this product

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