Overview

  • Product name

  • Description

    Goat polyclonal to CYP2C8
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cynomolgus monkey, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide:

    KNVALTRSYIREK

    (Human) by a Cysteine residue linker from the internal region of Human CYP2C8 (NP_000761.3; NP_001185782.1; NP_001185783.1).

  • Positive control

    • Human liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab126844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 56 kDa).

Target

  • Function

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CP2C8_HUMAN antibody
    • CPC8 antibody
    • CYP2C8 antibody
    • CYPIIC8 antibody
    • Cytochrome P450 2C8 antibody
    • Cytochrome P450 family 2 subfamily C polypeptide 8 antibody
    • Cytochrome P450 form 1 antibody
    • Cytochrome P450 IIC2 antibody
    • Cytochrome P450 MP-12 antibody
    • Cytochrome P450 MP-20 antibody
    • Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8 antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • MP 12/MP 20 antibody
    • P450 form 1 antibody
    • P450 IIC2 antibody
    • P450 MP 12/MP 20 antibody
    • S mephenytoin 4 hydroxylase antibody
    • S-mephenytoin 4-hydroxylase antibody
    • Xenobiotic monooxygenase antibody
    see all

Images

  • Anti-CYP2C8 antibody (ab126844) at 0.1 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 56 kDa

References

ab126844 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab126844.
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