Overview

  • Product name

  • Description

    Rabbit polyclonal to CYP2D6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Recombinant fragment corresponding to Human CYP2D6 aa 268-457.

  • Positive control

    • A431, HeLa, HepG2, MOLT4 and Raji cell lysates.
  • General notes

     This product was previously labelled as Cytochrome P450 2D6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab137426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 56 kDa.

Target

  • Function

    Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cholesterol 25-hydroxylase antibody
    • CP2D6_HUMAN antibody
    • CPD6 antibody
    • CYP2D antibody
    • CYP2D6 antibody
    • CYP2D7AP antibody
    • CYP2D7BP antibody
    • CYP2D7P2 antibody
    • CYP2D8P2 antibody
    • CYP2DL1 antibody
    • CYPIID6 antibody
    • Cytochrome P450 2D6 antibody
    • Cytochrome P450 DB1 antibody
    • Cytochrome P450 family 2 subfamily D member 6 antibody
    • Cytochrome P450 family 2 subfamily D polypeptide 6 antibody
    • Cytochrome P450-DB1 antibody
    • Debrisoquine 4 hydroxylase antibody
    • Debrisoquine 4-hydroxylase antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P450 DB1 antibody
    • P450C2D antibody
    • P450DB1 antibody
    • Xenobiotic monooxygenase antibody
    see all

Images

  • Anti-CYP2D6 antibody (ab137426) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 56 kDa



    7.5% SDS PAGE

References

This product has been referenced in:

  • Tanino T  et al. Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges. Eur J Drug Metab Pharmacokinet N/A:N/A (2018). Read more (PubMed: 30411300) »
  • Tanino T  et al. Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice. Drug Metab Dispos 44:1950-1957 (2016). Read more (PubMed: 27694226) »
See all 2 Publications for this product

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