Overview

  • Product name

  • Description

    Goat polyclonal to CYP2R1
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse CYP2R1 aa 405-418 (internal sequence) (Cysteine residue). NP_796356.2
    Sequence:

    (c)YSVHFDEKYWKDPD


    Database link: Q6VVW9

  • Positive control

    • WB: Mouse and rat testis tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab239217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml.

Target

  • Function

    Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
  • Involvement in disease

    Defects in CYP2R1 are the cause of rickets vitamin D-dependent type 1B (VDDR1B) [MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. A disorder caused by a selective deficiency of the active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. The patients sera have low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activityand low levels of 25-hydroxyvitamin D.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CP2R1_HUMAN antibody
    • CYP2R1 antibody
    • Cytochrome P450 2R1 antibody
    • Cytochrome P450 family 2 R1 antibody
    • Cytochrome P450 family 2 subfamily R polypeptide 1 antibody
    • EC 1.14.13.15 antibody
    • MGC4663 antibody
    • Vitamin D 25 hydroxylase antibody
    • Vitamin D 25-hydroxylase antibody
    see all

Images

  • All lanes : Anti-CYP2R1 antibody (ab239217) at 2 µg/ml

    Lane 1 : Mouse testis tissue lysate in RIPA buffer
    Lane 2 : Rat testis tissue lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.


    Detected by chemiluminescence.

References

ab239217 has not yet been referenced specifically in any publications.

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