Overview

  • Product name

  • Description

    Rabbit polyclonal to CYP8B1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids of Human CYP8B1 (Q9UNU6).

  • Positive control

    • 293 cell extract, Human liver carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab129845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 58 kDa.
IHC-P 1/50 - 1/100.

Target

  • Function

    Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
  • Tissue specificity

    Liver.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase antibody
    • 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase antibody
    • CP8B antibody
    • CP8B1_HUMAN antibody
    • CYP12 antibody
    • CYP8B1 antibody
    • CYPVIIIB1 antibody
    • Cytochrome P450 8B1 antibody
    • Cytochrome P450 subfamily VIIIB (sterol 12 alpha hydroxylase) polypeptide 1 antibody
    • Cytochrome P450, family 8, subfamily B, polypeptide 1 antibody
    • Sterol 12-alpha-hydroxylase antibody
    see all

Images

  • All lanes : Anti-CYP8B1 antibody (ab129845) at 1/500 dilution

    Lane 1 : 293 cell extract
    Lane 2 : 293 cell extract with synthesized peptide

    Predicted band size: 58 kDa

  • ab129845, at a dilution of 1/50, staining CYP8B1 in paraffin-embedded Human liver carcinoma tissue by Immunohistochemistry. The picture on the right was treated with synthesized peptide.

References

ab129845 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab129845.
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