Overview

  • Product name

    Cyproterone acetate, Androgen receptor antagonist
  • Description

    Androgen receptor antagonist
  • Biological description

    Androgen receptor antagonist (IC50 = 7.1 nM). Competes with dihydrotestosterone at androgen receptor sites. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    427-51-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Chloro-1β,2β-dihydro-17-hydroxy-3′H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
  • Molecular weight

    416.94
  • Molecular formula

    C24H29ClO4
  • PubChem identifier

    9880
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Arafa NM Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol Sci 13:966-76 (2010). Read more (PubMed: 21319455) »
  • Nguyen TV  et al. Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology 148:2936-43 (2007). Read more (PubMed: 17347309) »
  • Linderoth M  et al. Sex steroids in the female zebrafish (Danio rerio). Effects of cyproterone acetate and leachate-contaminated sediment extract. Aquat Toxicol 79:192-200 (2006). Read more (PubMed: 16844241) »

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