Anti-Cysteine Dioxygenase CDO1 antibody (ab234693)
Key features and details
- Rabbit polyclonal to Cysteine Dioxygenase CDO1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Cysteine Dioxygenase CDO1 antibody
See all Cysteine Dioxygenase CDO1 primary antibodies -
Description
Rabbit polyclonal to Cysteine Dioxygenase CDO1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Orangutan -
Immunogen
Recombinant full length protein corresponding to Human Cysteine Dioxygenase CDO1 aa 1 to the C-terminus.
Database link: Q16878 -
Positive control
- IHC-P: Human liver cancer and pancreatic cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab234693 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/20 - 1/200.
|
Notes |
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IHC-P
1/20 - 1/200. |
Target
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Function
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. -
Tissue specificity
Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells. -
Pathway
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. -
Sequence similarities
Belongs to the cysteine dioxygenase family. -
Post-translational
modificationsThe thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. - Information by UniProt
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Database links
- Entrez Gene: 514462 Cow
- Entrez Gene: 1036 Human
- Entrez Gene: 12583 Mouse
- Entrez Gene: 100174398 Orangutan
- Entrez Gene: 81718 Rat
- Omim: 603943 Human
- SwissProt: Q3SZU4 Cow
- SwissProt: Q16878 Human
see all -
Alternative names
- CDO 1 antibody
- CDO antibody
- CDO I antibody
see all
Images
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Paraffin-embedded human liver cancer tissue stained for Cysteine Dioxygenase CDO1 using ab234693 at 1/100 dilution in immunohistochemical analysis.
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Paraffin-embedded human pancreatic cancer tissue stained for Cysteine Dioxygenase CDO1 using ab234693 at 1/100 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab234693 has not yet been referenced specifically in any publications.