Overview

  • Product name
    Cytochalasin B, actin polymerization inhibitor
  • Description
    Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker.
  • Biological description
    Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker (IC50 = 4 μM). Inhibits I(Kur). Cytochalasin A (ab143481) analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo.
  • Purity
    > 97%
  • CAS Number
    14930-96-2
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
  • Molecular weight
    479.61
  • Molecular formula
    C29H37NO5
  • PubChem identifier
    5311281
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@@H]1CCC[C@@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)Cc4ccccc4)C)O)O
  • Source

    Drechslera dematoidea

  • Research areas

References

This product has been referenced in:
  • Giambelluca MS  et al. Characterization of the Na/HCO3(-) Cotransport in Human Neutrophils. Cell Physiol Biochem 33:982-90 (2014). Read more (PubMed: 24714077) »
  • Choi BH  et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol 289:C425-36 (2005). Read more (PubMed: 15800051) »
  • Bousquet PF  et al. Effects of cytochalasin B in culture and in vivo on murine Madison 109 lung carcinoma and on B16 melanoma. Cancer Res 50:1431-9 (1990). Read more (PubMed: 2302708) »
  • MacLean-Fletcher S & Pollard TD Mechanism of action of cytochalasin B on actin. Cell 20:329-41 (1980). Read more (PubMed: 6893016) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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