Overview

  • Product name

    Cytochalasin D, actin polymerization inhibitor
  • Description

    Potent actin polymerization inhibitor
  • Biological description

    Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
  • Purity

    > 98%
  • CAS Number

    22144-77-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6-12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione
  • Molecular weight

    507.63
  • Molecular formula

    C30H37NO6
  • PubChem identifier

    5458428
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O
  • Source

    Zygosporium mansonii

  • Research areas

References

This product has been referenced in:

  • Ohshiro J  et al. Modulation of TMEM16A-Channel Activity as Ca(2+) Activated Cl(-) Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein. J Pharmacol Sci 125:107-11 (2014). Read more (PubMed: 24770592) »
  • Shoji K  et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun 424:52-7 (2012). Read more (PubMed: 22728040) »
  • Wakatsuki T  et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci 114:1025-36 (2001). Read more (PubMed: 11181185) »
See all 2 Publications for this product

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