Cytochalasin D, actin polymerization inhibitor (ab143484)
Key features and details
- Potent actin polymerization inhibitor
- CAS Number: 22144-77-0
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Zygosporium mansonii
Overview
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Product name
Cytochalasin D, actin polymerization inhibitor -
Description
Potent actin polymerization inhibitor -
Biological description
Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable. -
Purity
> 98% -
CAS Number
22144-77-0 -
Chemical structure
Properties
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Chemical name
(3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6-12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione -
Molecular weight
507.63 -
Molecular formula
C30H37NO6 -
PubChem identifier
5458428 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O -
Source
Zygosporium mansonii
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Research areas
Images
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Chemical Structure - Cytochalasin D, actin polymerization inhibitor (ab143484)2D chemical structure image of ab143484, Cytochalasin D, actin polymerization inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab143484 has been referenced in 8 publications.
- Wang G et al. NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. Cell Death Dis 11:428 (2020). PubMed: 32513915
- Sun L et al. Salmonella Effector SpvB Disrupts Intestinal Epithelial Barrier Integrity for Bacterial Translocation. Front Cell Infect Microbiol 10:606541 (2020). PubMed: 33392110
- Xing B et al. GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in ß cells. J Cell Biol 218:855-870 (2019). PubMed: 30792230
- Zheng X et al. Actin filaments are dispensable for bulk autophagy in plants. Autophagy 15:2126-2141 (2019). PubMed: 30907219
- Lamri L et al. Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment. Genes Cells 24:731-745 (2019). PubMed: 31554018
- Zhang Y et al. Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+endosome trafficking. Sci Rep 7:8952 (2017). PubMed: 28827576
- Isner JC et al. Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. New Phytol 215:1059-1067 (2017). PubMed: 28636198
- Wu F et al. Chimeric antibody targeting SRPK-1 in the treatment of non-small cell lung cancer by inhibiting growth, migration and invasion. Mol Med Rep 16:2121-2127 (2017). PubMed: 28656224