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    cytochalasin-d-actin-polymerization-inhibitor-ab143484.pdf

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Biochemicals Chemical Type Biochemicals
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Cytochalasin D, actin polymerization inhibitor (ab143484)

  • Datasheet
  • SDS
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Chemical Structure - Cytochalasin D, actin polymerization inhibitor (ab143484)

    Key features and details

    • Potent actin polymerization inhibitor
    • CAS Number: 22144-77-0
    • Purity: > 98%
    • Soluble in ethanol to 10 mM and in DMSO to 50 mM
    • Form / State: Solid
    • Source: Zygosporium mansonii

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    Overview

    • Product name

      Cytochalasin D, actin polymerization inhibitor
    • Description

      Potent actin polymerization inhibitor
    • Biological description

      Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
    • Purity

      > 98%
    • CAS Number

      22144-77-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6-12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione
    • Molecular weight

      507.63
    • Molecular formula

      C30H37NO6
    • PubChem identifier

      5458428
    • Storage instructions

      Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in ethanol to 10 mM and in DMSO to 50 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O
    • Source

      Zygosporium mansonii

    • Research areas

      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Signaling
      • Apoptosis & cell cycle
      • p53
      • Activators
      • Biochemicals
      • Pharmacology
      • Signaling
      • Cytoskeleton & motor proteins
      • Actin

    Images

    • Chemical Structure - Cytochalasin D, actin polymerization inhibitor (ab143484)
      Chemical Structure - Cytochalasin D, actin polymerization inhibitor (ab143484)
      2D chemical structure image of ab143484, Cytochalasin D, actin polymerization inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (8)

    Publishing research using ab143484? Please let us know so that we can cite the reference in this datasheet.

    ab143484 has been referenced in 8 publications.

    • Wang G  et al. NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. Cell Death Dis 11:428 (2020). PubMed: 32513915
    • Sun L  et al. Salmonella Effector SpvB Disrupts Intestinal Epithelial Barrier Integrity for Bacterial Translocation. Front Cell Infect Microbiol 10:606541 (2020). PubMed: 33392110
    • Xing B  et al. GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in ß cells. J Cell Biol 218:855-870 (2019). PubMed: 30792230
    • Zheng X  et al. Actin filaments are dispensable for bulk autophagy in plants. Autophagy 15:2126-2141 (2019). PubMed: 30907219
    • Lamri L  et al. Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment. Genes Cells 24:731-745 (2019). PubMed: 31554018
    • Zhang Y  et al. Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+endosome trafficking. Sci Rep 7:8952 (2017). PubMed: 28827576
    • Isner JC  et al. Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. New Phytol 215:1059-1067 (2017). PubMed: 28636198
    • Wu F  et al. Chimeric antibody targeting SRPK-1 in the treatment of non-small cell lung cancer by inhibiting growth, migration and invasion. Mol Med Rep 16:2121-2127 (2017). PubMed: 28656224

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