Overview

  • Product name
    Cytochalasin E, actin-polymerization inhibitor
  • Description
    Cell-permeable actin-polymerization inhibitor
  • Biological description
    Cell-permeable actin-polymerization inhibitor. Shows potent antiproliferative (IC50 = 11 nM) and antiangiogenic effects. Active in vivo.
  • Purity
    > 99%
  • CAS Number
    36011-19-5
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    6,7-Epoxy-10-phenyl-5,6,16,18-tetramethyl-21,23-dioxa-(13)cytochalas-13,19-diene-17,22-dione
  • Molecular weight
    495.60
  • Molecular formula
    C28H33NO7
  • PubChem identifier
    5458385
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C
  • Source

    Synthetic

  • Research areas

Images

  • Cytochalasin E inhibits actin polymerization in C6 glioma cells. Cells were incubated in the absence (A) or presence (B) of 10 µM Cytochalasin E (ab141788) for 1 h at 37°C. The figure shows dual staining using Rhodamine-conjugated-Palloidine (red, for actin filament staining) and DAPI for nucleus staining (blue).

References

This product has been referenced in:
  • Liu R  et al. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans. J Nat Prod 69:871-5 (2006). Read more (PubMed: 16792402) »
  • Udagawa T  et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther 294:421-7 (2000). Read more (PubMed: 10900214) »
  • Gan Y  et al. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures. Pharm Res 15:1760-6 (1998). Read more (PubMed: 9834000) »

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