Anti-Cytochrome b5 antibody (ab23852)
Key features and details
- Goat polyclonal to Cytochrome b5
- Suitable for: WB
- Reacts with: Rat, Rabbit, Human
- Isotype: IgG
Overview
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Product name
Anti-Cytochrome b5 antibody
See all Cytochrome b5 primary antibodies -
Description
Goat polyclonal to Cytochrome b5 -
Host species
Goat -
Specificity
Non-specific cross-reactivity with 50 and 60 kDa species. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Rabbit, Human -
Immunogen
Full length native protein (purified) (Rabbit).
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide -
Concentration information loading... -
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab23852 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000. Predicted molecular weight: 15 kDa. |
Target
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Function
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. -
Involvement in disease
Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:250790]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. -
Sequence similarities
Belongs to the cytochrome b5 family.
Contains 1 cytochrome b5 heme-binding domain. -
Cellular localization
Cytoplasm and Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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Database links
- Entrez Gene: 1528 Human
- Entrez Gene: 64001 Rat
- Omim: 613218 Human
- SwissProt: P00167 Human
- SwissProt: P00173 Rat
- Unigene: 465413 Human
- Unigene: 1055 Rat
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Alternative names
- CYB 5 antibody
- CYB 5A antibody
- CYB5 antibody
see all
Datasheets and documents
References
ab23852 has been referenced in 2 publications.
- Samhan-Arias AK et al. Stimulation and clustering of cytochrome b(5) reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons. J Proteomics : (2011). WB . PubMed: 22200675
- Samhan-Arias AK et al. Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane. Mol Cell Neurosci 40:14-26 (2009). Rat . PubMed: 18973815
