Key features and details
- Mouse monoclonal [C10-7] to Cytochrome P450 1A1 + 1A2
- Suitable for: ELISA, WB, IHC-P
- Reacts with: Rainbow trout
- Isotype: IgG3
Product nameAnti-Cytochrome P450 1A1 + 1A2 antibody [C10-7]
See all Cytochrome P450 1A1 + 1A2 primary antibodies
DescriptionMouse monoclonal [C10-7] to Cytochrome P450 1A1 + 1A2
Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
Species reactivityReacts with: Rainbow trout
- Liver microsomes from beta naphtoflavone treated (BNF) or tetrachlorodibenzo-p-dioxin (TCDD) treated fish.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.1% Sodium azide
Constituents: 1% BSA, 0.88% Sodium chloride, 1.64% Sodium phosphate
Concentration information loading...
PurityProtein A purified
Light chain typekappa
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab37130 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol (see references).
WB: 1/50 - 1/500. Predicted molecular weight: 55 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceCytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.
Cellular localizationEndoplasmic reticulum
- Aryl hydrocarbon hydroxylase antibody
- CP11 antibody
- CP12 antibody
ab37130 has not yet been referenced specifically in any publications.