Overview

  • Product name

    Anti-Cytochrome P450 1A2 antibody
    See all Cytochrome P450 1A2 primary antibodies
  • Description

    Rabbit polyclonal to Cytochrome P450 1A2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cynomolgus monkeyDoes not react with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human Cytochrome P450 1A2 aa 284-298 (internal sequence).
    Sequence:

    TGALFKHSKKGPRAS


    Database link: P05177

Properties

Applications

Our Abpromise guarantee covers the use of ab195638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 58 kDa.

Target

  • Function

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
  • Tissue specificity

    Liver.
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Aryl hydrocarbon hydroxylase antibody
    • CP 12 antibody
    • CP12 antibody
    • CP1A2_HUMAN antibody
    • CYP1A2 antibody
    • CYPIA2 antibody
    • Cytochrome P(3)450 antibody
    • Cytochrome P450 1A2 antibody
    • Cytochrome P450 4 antibody
    • Cytochrome P450 family 1 polypeptide 2 antibody
    • Cytochrome P450 family 1 subfamily A polypeptide 2 antibody
    • Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody
    • Cytochrome P450-P3 antibody
    • Cytochrome P4501A2 antibody
    • Dioxin inducable P3 450 antibody
    • Flavoprotein linked monooxygenase antibody
    • Flavoprotein-linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P(3)450 antibody
    • P3 450 antibody
    • P450 4 antibody
    • P450 form 4 antibody
    • P450 P3 antibody
    • P450(PA) antibody
    • Xenobiotic monooxygenase antibody
    see all

References

ab195638 has not yet been referenced specifically in any publications.

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