Key features and details
- Rabbit polyclonal to Cytochrome P450 1A2
- Suitable for: IHC-P
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Cytochrome P450 1A2 antibody
See all Cytochrome P450 1A2 primary antibodies
DescriptionRabbit polyclonal to Cytochrome P450 1A2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Rat
Predicted to work with: Mouse, Human
- Rat liver tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 50% Glycerol, 1% BSA
Concentration information loading...
PurityProtein A purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab217377 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.
When using a fluorescent probe the recommended dilution is 1/50 – 1/200.
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Sequence similaritiesBelongs to the cytochrome P450 family.
Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
- Aryl hydrocarbon hydroxylase antibody
- CP 12 antibody
- CP12 antibody
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat liver tissue labeling Cytochrome P450 1A2 with ab217377 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat liver tissue labeling Cytochrome P450 1A2 with ab217377 at 1/200 dilution followed by conjugation to the secondary antibody and DAPI staining.
ab217377 has not yet been referenced specifically in any publications.