Product nameAnti-Cytochrome P450 1A2 antibody
See all Cytochrome P450 1A2 primary antibodies
DescriptionRabbit polyclonal to Cytochrome P450 1A2
SpecificityDetects Cytochrome P450 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Other Immunogen Type (His-tag) corresponding to Human Cytochrome P450 1A2 . Purified, His-tagged, full length human P450 1A2 fusion protein.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: 99% PBS
Concentration information loading...
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab3569 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 56 kDa (predicted molecular weight: 58 kDa).
This antibody detects an ~56 kDa protein representing recombinant human P450 1A2.
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Sequence similaritiesBelongs to the cytochrome P450 family.
Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
- Aryl hydrocarbon hydroxylase antibody
- CP 12 antibody
- CP12 antibody
ab3569 has not yet been referenced specifically in any publications.