Overview

  • Product name
    Anti-Cytochrome P450 1A2 antibody
    See all Cytochrome P450 1A2 primary antibodies
  • Description
    Rabbit polyclonal to Cytochrome P450 1A2
  • Host species
    Rabbit
  • Specificity
    Detects Cytochrome P450 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Other Immunogen Type (His-tag) corresponding to Human Cytochrome P450 1A2 . Purified, His-tagged, full length human P450 1A2 fusion protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab3569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 56 kDa (predicted molecular weight: 58 kDa).

This antibody detects an ~56 kDa protein representing recombinant human P450 1A2.

Target

  • Function
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
  • Tissue specificity
    Liver.
  • Sequence similarities
    Belongs to the cytochrome P450 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aryl hydrocarbon hydroxylase antibody
    • CP 12 antibody
    • CP12 antibody
    • CP1A2_HUMAN antibody
    • CYP1A2 antibody
    • CYPIA2 antibody
    • Cytochrome P(3)450 antibody
    • Cytochrome P450 1A2 antibody
    • Cytochrome P450 4 antibody
    • Cytochrome P450 family 1 polypeptide 2 antibody
    • Cytochrome P450 family 1 subfamily A polypeptide 2 antibody
    • Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody
    • Cytochrome P450-P3 antibody
    • Cytochrome P4501A2 antibody
    • Dioxin inducable P3 450 antibody
    • Flavoprotein linked monooxygenase antibody
    • Microsomal monooxygenase antibody
    • P(3)450 antibody
    • P3 450 antibody
    • P450 4 antibody
    • P450 form 4 antibody
    • P450 P3 antibody
    • P450(PA) antibody
    • Xenobiotic monooxygenase antibody
    see all

Images

  • ab3569 at a dilution of 1/1000 staining recombinant human cytochrome P450 1A2 by Western blot.

References

ab3569 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer



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