Anti-Cytochrome P450 2E1 antibody (ab28146)

Rabbit polyclonal Cytochrome P450 2E1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Rabbit, Horse, Guinea pig, Dog, Human, Monkey. Cited in 55 publication(s).

Publishing research using ab28146? Please let us know so that we can cite the reference in this datasheet.

ab28146 has been referenced in 66 publications.

  • Guan F  et al. New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium. J Am Heart Assoc 8:e009871 (2019). PubMed: 30563421
  • Maisto R  et al. ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5. Cell Cycle 18:413-424 (2019). PubMed: 30739530
  • Cui BW  et al. Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway. Am J Chin Med 47:577-594 (2019). PubMed: 30974967
  • Chae YJ  et al. The Use of Foxa2-Overexpressing Adipose Tissue-Derived Stem Cells in a Scaffold System Attenuates Acute Liver Injury. Gut Liver 13:450-460 (2019). PubMed: 30602218
  • Winkler S  et al. Immune-Deficient Pfp/Rag2-/- Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice. Cells 8:N/A (2019). PubMed: 31349725
  • Peng WC  et al. Inflammatory Cytokine TNFa Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell 175:1607-1619.e15 (2018). PubMed: 30500539
  • Cho YE  et al. Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice. Sci Rep 8:16070 (2018). PubMed: 30375433
  • Jian T  et al. Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways. Int J Mol Sci 19:N/A (2018). PubMed: 30275422
  • Zhang S  et al. Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration. Gastroenterology 154:1421-1434 (2018). PubMed: 29274368
  • Runtz L  et al. Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures. Epilepsia 59:123-134 (2018). PubMed: 29125184
  • Serra M  et al. Evidence of Amniotic Epithelial Cell Differentiation toward Hepatic Sinusoidal Endothelial Cells. Cell Transplant 27:23-30 (2018). PubMed: 29562778
  • Wang Y  et al. Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury. JCI Insight 3:N/A (2018). PubMed: 29669937
  • Tietze L  et al. Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5+ stem cells. Exp Cell Res 369:335-347 (2018). PubMed: 29864400
  • Wang L  et al. Rosuvastatin relieves myocardial ischemia/reperfusion injury by upregulating PPAR-? and UCP2. Mol Med Rep 18:789-798 (2018). PubMed: 29845235
  • Hao L  et al. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. Redox Biol 14:626-636 (2018). WB ; Mouse . PubMed: 29156373
  • Donepudi AC  et al. Deficiency of cholesterol 7a-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. Hepatol Commun 2:99-112 (2018). PubMed: 29404516
  • Wang Y  et al. Herba Gelsemii elegantis is detoxified by ramulus et folium Mussaendae pubescentis extract by modulating hepatic cytochrome P450 and glutathione S-transferase enzymes in rats. Exp Ther Med 15:226-234 (2018). PubMed: 29375684
  • Qin D  et al. Ultrasound-targeted microbubble destruction-mediated miR-205 enhances cisplatin cytotoxicity in prostate cancer cells. Mol Med Rep 18:3242-3250 (2018). PubMed: 30066866
  • Tanino T  et al. Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges. Eur J Drug Metab Pharmacokinet N/A:N/A (2018). PubMed: 30411300
  • Kang HT  et al. Effect of Stem Cell Treatment on Acute Liver Failure Model Using Scaffold. Dig Dis Sci N/A:N/A (2018). PubMed: 30421375
  • Gill P  et al. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep 7:12331 (2017). WB . PubMed: 28951593
  • Lu Y  et al. Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes. BMC Complement Altern Med 17:15 (2017). PubMed: 28056947
  • Stock P  et al. Impairment of Host Liver Repopulation by Transplanted Hepatocytes in Aged Rats and the Release by Short-Term Growth Hormone Treatment. Am J Pathol 187:553-569 (2017). PubMed: 28088007
  • Sun X  et al. Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. Cancer Cell 32:574-589.e6 (2017). PubMed: 29136504
  • Uehara S  et al. Functional characterization and tissue expression of marmoset cytochrome P450 2E1. Biopharm Drug Dispos N/A:N/A (2017). PubMed: 28474789
  • McCracken JM  et al. C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice. Gene Expr 17:187-205 (2017). PubMed: 28234577
  • Scheving LA  et al. Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis. Am J Physiol Gastrointest Liver Physiol 311:G807-G816 (2016). PubMed: 27586651
  • Smirnova OA  et al. Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. Oxid Med Cell Longev 2016:8341937 (2016). PubMed: 27200149
  • Richter M  et al. Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system. Toxicol Res (Camb) 5:278-290 (2016). PubMed: 30090344
  • Song M  et al. Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response. Alcohol Clin Exp Res 40:518-28 (2016). PubMed: 26858005
  • Sun X  et al. Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell 18:456-66 (2016). PubMed: 27044474
  • Nygaard S  et al. A universal system to select gene-modified hepatocytes in vivo. Sci Transl Med 8:342ra79 (2016). PubMed: 27280686
  • Tanino T  et al. Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice. Drug Metab Dispos 44:1950-1957 (2016). PubMed: 27694226
  • Duan L  et al. Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. Food Chem Toxicol 98:107-118 (2016). PubMed: 27773698
  • Mohamad NE  et al. Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice. Chin Med 10:3 (2015). WB . PubMed: 25699088
  • Ivanov AV  et al. HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells. Viruses 7:2745-70 (2015). PubMed: 26035647
  • Gi M  et al. Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice. Toxicol Sci 145:196-208 (2015). IHC-P ; Mouse, Hamster . PubMed: 25711234
  • Hattori Y  et al. Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions. J Ovarian Res 8:73 (2015). PubMed: 26576867
  • Wilson CL  et al. NF?B1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun 6:6818 (2015). WB ; Mouse . PubMed: 25879839
  • Boussadia B  et al. Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. Neuroscience 281C:124-134 (2014). IHC-P ; Mouse . PubMed: 25280786
  • Manley S  et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol 2:991-1002 (2014). PubMed: 25460735
  • Spruiell K  et al. Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. Biochem Pharmacol 89:399-412 (2014). PubMed: 24721462
  • Sonnino C  et al. Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra. Mol Med 20:486-9 (2014). PubMed: 25121719
  • Probert PM  et al. Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies. Toxicol Sci 137:350-70 (2014). ICC/IF ; Rat . PubMed: 24235770
  • Nixon BJ  et al. Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure. PLoS One 9:e94904 (2014). ICC/IF ; Mouse . PubMed: 24788432
  • Sun Q  et al. Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 307:G313-22 (2014). PubMed: 24924749
  • Goudarzi M  et al. PPARß/d modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Toxicology 311:87-98 (2013). PubMed: 23851158
  • Zhong W  et al. Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PLoS One 8:e76522 (2013). WB, IHC-P ; Mouse . PubMed: 24155903
  • Kang YB  et al. Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid. Biofabrication 5:045008 (2013). Rat . PubMed: 24280542
  • Leung T  et al. Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res 15:R107 (2013). WB . PubMed: 24207099
  • Shirakami Y  et al. Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration. Carcinogenesis 33:268-74 (2012). WB ; Mouse . PubMed: 22116467
  • Kutay H  et al. Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. PLoS One 7:e41949 (2012). WB . PubMed: 22905112
  • Hoque R  et al. P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am J Physiol Gastrointest Liver Physiol 302:G1171-9 (2012). WB ; Mouse . PubMed: 22383490
  • Zeybel M  et al. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med 18:1369-77 (2012). WB, RT-PCR ; Rat . PubMed: 22941276
  • D'Ambrosio DN  et al. Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. PLoS One 6:e24993 (2011). WB ; Mouse . PubMed: 21949825
  • Zhang W  et al. Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice. FEBS J 278:1484-92 (2011). PubMed: 21352494
  • Schäfer A  et al. Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation. Diabetes 59:2001-9 (2010). WB ; Rat . PubMed: 20522591
  • Getachew Y  et al. Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. Biochem Pharmacol 79:1363-71 (2010). WB ; Mouse . PubMed: 20036646
  • Piguet AC  et al. Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clin Sci (Lond) 118:401-10 (2010). WB ; Mouse . PubMed: 19832698
  • Posadas I  et al. Acetaminophen induces apoptosis in rat cortical neurons. PLoS One 5:e15360 (2010). WB ; Rat . PubMed: 21170329
  • Seibert C  et al. Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry. J Proteome Res 8:1672-81 (2009). WB ; Human . PubMed: 19714871
  • Agus HH  et al. Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle). Phytother Res 23:1763-70 (2009). WB ; Rat . PubMed: 19441062
  • Scheving LA  et al. Cultured Rat Hepatocytes Upregulate Akt and ERK in an ErbB-2 Dependent Manner. Am J Physiol Gastrointest Liver Physiol : (2008). PubMed: 18535289
  • Campion SN  et al. Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Am J Physiol Gastrointest Liver Physiol 295:G294-304 (2008). PubMed: 18556419
  • Lane CS  et al. Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling. Mol Cell Proteomics 6:953-62 (2007). WB ; Human . PubMed: 17296599
  • Simper-Ronan R  et al. Cholangiocyte marker-positive and -negative fetal liver cells differ significantly in their ability to regenerate the livers of adult rats exposed to retrorsine. Development 133:4269-79 (2006). IHC-Fr . PubMed: 17021035

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