Key features and details
- Rabbit polyclonal to Cytokeratin 4
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cytokeratin 4 antibody
See all Cytokeratin 4 primary antibodies
DescriptionRabbit polyclonal to Cytokeratin 4
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Fusion protein within Human Cytokeratin 4 (internal sequence). The exact sequence is proprietary. (BC042174) The identity of the protein fusion partner is GST.
Database link: P19013
- Human liver cancer tissue lysate and Human cervical cancer tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197385 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/5 - 1/20.|
|WB||1/500 - 1/2000. Predicted molecular weight: 57 kDa.|
Tissue specificityDetected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Involvement in diseaseDefects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
Sequence similaritiesBelongs to the intermediate filament family.
- Information by UniProt
FormLocalisation: Intermediate filament (Cytoskeleton).
- CK 4 antibody
- CK-4 antibody
- CK4 antibody
ab197385 has not yet been referenced specifically in any publications.