Key features and details
- Mouse monoclonal [16.4] to Cytokeratin 5 + 14
- Reacts with: Human
- Isotype: IgG2a
Product nameAnti-Cytokeratin 5 + 14 antibody [16.4]
See all Cytokeratin 5 + 14 primary antibodies
DescriptionMouse monoclonal [16.4] to Cytokeratin 5 + 14
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Cytokeratin 5 + 14. Hybridoma produced by the fusion of splenocytes from mice immunized with cytokeratin enriched extract of feline tongue epithelium and mouse myeloma cells.
Database link: P02533
Cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.08% Sodium azide
Concentration information loading...
PurityProtein A/G purified
RelevanceCytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
Cellular localizationCytoplasmic; Basal layer
- CK 14 antibody
- CK 5 antibody
- DDD antibody
ab16570 has been referenced in 3 publications.
- Arthur GK et al. KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells. PLoS One 10:e0145259 (2015). PubMed: 26689552
- Woodman LB et al. Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition. Chest 143:1656-66 (2013). ICC/IF ; Human . PubMed: 23238614
- Stenzinger A et al. Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes. Cells Tissues Organs 184:76-87 (2006). PubMed: 17361080