Overview

  • Product name

    Anti-Cytokeratin 6a antibody [KRT6A/2368]
    See all Cytokeratin 6a primary antibodies
  • Description

    Mouse monoclonal [KRT6A/2368] to Cytokeratin 6a
  • Host species

    Mouse
  • Tested applications

    Suitable for: Protein Array, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human Cytokeratin 6a.
    Database link: P02538

  • Positive control

    • IHC-P: Human basal cell, basal cell carcinoma and prostate carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Protein Array Use at an assay dependent concentration.
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Incubate with primary antibody for 30 minutes at RT.

Target

  • Tissue specificity

    Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
  • Involvement in disease

    Defects in KRT6A are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
  • Sequence similarities

    Belongs to the intermediate filament family.
  • Information by UniProt
  • Database links

  • Alternative names

    • CK-6A antibody
    • CK-6D antibody
    • CK6A antibody
    • CK6C antibody
    • CK6D antibody
    • Cytokeratin-6A antibody
    • Cytokeratin-6D antibody
    • K2C6A_HUMAN antibody
    • K6A antibody
    • K6C antibody
    • K6D antibody
    • keratin 6A antibody
    • Keratin antibody
    • Keratin, type II cytoskeletal 6A antibody
    • Keratin-6A antibody
    • Krt6a antibody
    • KRT6C antibody
    • KRT6D antibody
    • type II cytoskeletal 6A antibody
    • Type-II keratin Kb6 antibody
    see all

Images

  • ab238013 was tested in protein array against over 19000 different full-length human proteins.
    Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
    A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
  • Formalin-fixed, paraffin-embedded human prostate carcinoma tissue stained for Cytokeratin 6 using ab238013 at 2 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human basal cell tissue stained for Cytokeratin 6 using ab238013 at 2 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human basal cell carcinoma tissue stained for Cytokeratin 6 using ab238013 at 2 μg/ml in immunohistochemical analysis.

References

ab238013 has not yet been referenced specifically in any publications.

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