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The immunogen sequence that generated cytokeratin antibody ab53280 is 93% identical to the rat cytokeratin type II cytoskeletal 8, accession NP_955402.1. So we expect cross-reaction but do not have experimental evidence. The potential for cross-reaction with cytokeratin 18 seems less likely. We have experimental evidence of reaction with human cytokeratin 18 but this was unexpected. The immunogen has minimal homology with that protein, and none with rat cytokeratin 18.
Tom RuyleAbcam Scientific Support
Answered on Mar 11 2016